C1qR1/CD93 Fc Chimera Protein, Human
SKU: 29763647328

C1qR1/CD93 Fc Chimera Protein, Human

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Description

C1qR1/CD93 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms AA4 Antigen; C1q R1; C1q receptor 1; C1q Rp; C1q MBL SPA receptor; C1qR(P); C1qR1; C1qRp; CD93 antigenC1qR; CD93 molecule; CD93; CDw93C1QR1; Collectin Receptor; Complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23. 1; ECSM3; Ly68; Matrix remodeling associated protein 4; matrix remodelling associated 4; MXRA4

Product Specification


Species Human
Synonyms AA4 Antigen; C1q R1; C1q receptor 1; C1q Rp; C1q/MBL/SPA receptor; C1qR(P); C1qR1; C1qRp; CD93 antigenC1qR; CD93 molecule; CD93; CDw93C1QR1; Collectin Receptor; Complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix-remodeling-associated protein 4; matrix-remodelling associated 4; MXRA4
Accession Q9NPY3
Amino Acid Sequence

Thr22-Lys580 with Human IgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight 100-120kDa (Reducing)
Purity >95% by SDS-PAGE & SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

Greenlee-Wacker M C. et al. (2011) Membrane-Associated CD93 Regulates Leukocyte Migration and C1q-Hemolytic Activity during Murine Peritonitis. J. Immunol. 187: 3353-3361.
Nepomuceno R R. et al. (1997) cDNA cloning and primary structure analysis of C1qRp, the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. Immunity. 6: 119-129.
Nepomuceno R R. et al. (1998) C1qRp, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets. J. Immunol. 160: 1929-1935.

Background

Complement component 1q (C1q) receptor 1 (C1qR1, also known as C1qRp, or cluster of differentiation 93-CD93) is a 126-kDa type 1 transmembrane glycoprotein expressed in endothelial and hematopoietic cells, and responsible for C1q-induced phagocytosis. CD93 contains one C-type lectin domain and five EGF-like domains. Mature human CD93 consists of a 557 amino acid (aa) extracellular domain (ECD) with one C‑type lectin domain, four tandem EGF‑like domains, and a mucin‑like domain, followed by a 21 aa transmembrane segment and a 51 aa cytoplasmic domain. CD93 is receptor for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). Soluble CD93 promotes the differentiation of monocytes to macrophages, phagocytosis of apoptotic cells, and inflammatory responsiveness to multiple TLR ligands.

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SKU: 29763647328

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Lydia Wormsley
San Leandro, US
★★★★★ 5
Great book!
Format: Paperback
Wonderful, helpful, insightful. Points out many of the key "sore spots" that can sour a marriage if left unmanaged, and how to address them. Very helpful, whether as a premarital counseling book, a book for the happily married couple, or even for the unhappily married couple willing to set their relationship right. Must read!
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Reviewed in the United States on February 10, 2026
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MISTY C.
Louisville, US
★★★★★ 5
Great buy
Format: Paperback
Good read.
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Reviewed in the United States on May 28, 2026
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Jenna H
Belleville, US
★★★★★ 4
Good discussion book to eliminate conflict between couples
Format: Kindle
Use this book as a checklist of things you should discuss with your partner - especially if you're considering or are in a long-term relationship. It explains each topic, why it's a likely source of conflict, how to prevent the conflicts, and includes questions for discussion between partners. Understanding and discussing these topics may not feel romantic and fun, and some of the conversations may be challenging for couples who aren't accustomed to such discussions. Do it anyway though because it will eliminate future conflicts before the conflicts even begin and make your relationship run smoother, last longer, and be a source of relaxation and contentment for you both. I'm speaking from experience here. If you are new to the study of this topic, this book will be extremely valuable for you. If you've already studied interpersonal relationships, preemptive conflict resolution, and collaborative negotiation tactics, it's still a great checklist of topics to discuss with your partner. I'm on this end of the spectrum, hence 4 of 5 stars because I'm familiar with the author's other work and this book didn't contain much new content. As a compact, all-in-one, relationship discussion guide though, it's great and worth reading and having on hand for future reference for new relationships or for when new conflicts crop up.
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Reviewed in the United States on March 3, 2018
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Johanna
Boise, US
★★★★★ 5
Easy to read
Format: Paperback
Very interesting book!
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Reviewed in the United States on April 20, 2026
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Susan
Belleville, US
★★★★★ 5
Great for Everyone!
Format: Paperback
This book is very useful to prepare people for marriage and I would recommend it for teens (even if they're not in a relationship), engaged couples, and even those already married since this provides realistic information about love and that not everything in a relationship is easy. It also helps people understand and attempt to loosely preset chores around the house and understand what to do with the extra money earned that isn't needed for bills. While I was already aware and have read about the 5 love languages, that is only briefly covered in one chapter while the rest provides other information so if you already read the 5 Love Languages book understand that there is a lot more involved in this book than that concept. The concept that I want to highlight in this book that I haven't read about before was the 5 Different Ways to Apologize. Increasingly, I think people need to be aware that what we consider to be a 'sincere apology' isn't necessarily the same as everyone else's though there are 5 of them that are fairly common. I was surprised when I found what I thought to be a sincere apology was listed word-for-word! This concept alone can be applied to anyone you socialize with and I especially recommend this piece if you are having apology problems between your friend, significant other, coworkers, and/or boss. Teens and those single will be able to learn a lot from this book, especially to realize that people, on average, are no longer "falling in love" within two years of the relationship and I think this would help them understand that relationships take a lot of work even when it's not convenient for you. Giving them an understanding of how to be flexible when apologizing and to know that people feel loved according to different love languages will make them more aware of how to improve their friendships and relationships in the future. Finally, there is reinforcement in being willing to do chores even if they're not popular and generally establishing healthy spending habits. I personally found this book to be thrilling and Gary Chapman successfully backs up some of his findings with Psychological research and definitions. I loved it so much that I read it in one sitting and now I'm getting my teen friends and budding couples into reading it. Awesome book; give it a try if you haven't already! (:
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Reviewed in the United States on June 30, 2016

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