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Description
CD117/c-Kit His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CD117, SCFR, c Kit, KIT Accession XP_005555332. 1 Amino Acid Sequence Gln26 Pro520, with C terminal His Expression System HEK293 Molecular Weight 75 95kDa (Reducing) Purity 95% by SDS PAGE &SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Cynomolgus |
| Synonyms | CD117, SCFR, c-Kit, KIT |
| Accession | XP_005555332.1 |
| Amino Acid Sequence | Gln26-Pro520, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 75-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &＞SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Wang H, Ni R, Wang A, Liu B. CD117 expression predicted FLT3 mutation in T-cell acute lymphoblastic leukemia. EJHaem. 2024 Feb 18;5(1):294-295. |
Background
Mast/stem cell growth factor receptor Kit (c-Kit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
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