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Description
IL-3R alpha/CD123 His Tag Protein, CanineProduct Specification Species Canine Synonyms CD123 antigen; CD123; hIL3Ra; hIL 3Ra; IL 3 R alpha; IL 3 receptor subunit alpha; IL3R alpha; IL 3R alpha; IL 3R subunit alpha; IL3R; IL3RA; IL 3Ra; IL 3R alpha; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor, alpha (low affinity); interleukin 3 receptor subunit alpha; MGC34174 Accession XP_038305195. 1 Amino Acid Sequence Ser33 Asp315, with C terminal His Expression System HEK293 Molecular Weight 43 55kDa
Product Specification
| Species | Canine |
| Synonyms | CD123 antigen; CD123; hIL3Ra; hIL-3Ra; IL-3 R alpha; IL-3 receptor subunit alpha; IL3R alpha; IL-3R alpha; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; MGC34174 |
| Accession | XP_038305195.1 |
| Amino Acid Sequence | Ser33-Asp315, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 43-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &＞95% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. LIU, KEQIANG, ZHU, MENGRU, HUANG, YAO, et al. CD123 and its potential clinical application in leukemias [J]. Life sciences,2015,122(1):59-64. |
Background
Interleukin-3 receptor α (IL-3Rα) is the α subunit of the ligand-specific IL-3R and initiates intracellular signaling in response to IL-3. The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. IL-3 amplifies proinflammatory signaling and cytokine storm in murine sepsis models. In vitro, IL-3 stimulation promoted IL-3Rα proteasomal degradation dependent on RNFT2 (RING finger transmembrane-domain containing protein 2, also TMEM118), and we identified IL-3Rα lysine 357 as a ubiquitin acceptor site. Researches identify RNFT2 as a negative regulator of IL-3Rα and show a potential role for the RNFT2/IL-3Rα/IL-3 axis in regulating innate immune responses in the lung.
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4.4 ★★★★★
Based on 1906 reviews
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Product Reviews
★★★★★ 5
Dog loves it
Great durability and unpredictability. Dog loves it and we love it. It’ll last a long time.
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Reviewed in the United States on October 29, 2023
★★★★★ 4
It's A Beast - But It'll Last Forever
Color: Large size (ø 7.4")
This big orange interactive dog toy does a few things differently—and mostly, it does them right.
First, there are no batteries and no charging required. The internal noise maker is activated by movement, producing little squeaks and quacks that grab a dog’s attention without turning into an electronic science experiment. Second—and more importantly—this thing is built to last. It’s designed to work as both a ball and a tug toy, which means it’s far tougher than the typical interactive balls that get shredded in short order. I fully expect this one to stick around for a long time.
That said, the reaction from my dogs was… mixed. All of them were a bit spooked at first. The sounds made them curious but cautious. My Border Collie was the first to commit and play with it, and she gave it a solid try. After a while, though, interest faded and the toy ended up sitting on the floor largely ignored.
I can get them engaged if I roll it around and hype things up, but the two dogs that usually love tug-of-war haven’t latched onto this one yet. My guess is this toy will shine more outdoors. Once spring rolls around and it’s flying across the yard instead of the living room floor, I suspect it’ll get a lot more action. My dogs tend to burn energy—and enthusiasm—much faster outside.
If you have a heavy chewer that destroys fragile interactive toys (and drains your wallet in the process), this is a very welcome alternative. Considering how quickly $35–$50 electronic balls can meet their end, this toy earns its place in the basket for durability alone.
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Reviewed in the United States on December 16, 2025
★★★★★ 3
Good for non chewers
Color: Large size (ø 7.4")
Dog lived it for the 4 minutes before he chewed a large hole in it. Definitely not for heavy chewers.
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Reviewed in the United States on April 28, 2026
★★★★★ 1
Terrible
Color: Medium size (ø 5.5")
Received 39 minutes ago. Chewed up in tiny pieces already. Feels like hard plastic in a cheap car.
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Reviewed in the United States on December 12, 2025
★★★★★ 5
This is actually a fantastic dog toy!
Color: Large size (ø 7.4")
I originally got this for my golden retriever. He loves all things ball-shaped and I figured the handles would make this really easy for him to carry and for me to tug. It was a fantastic hit not only with the retriever but my lab and even my older Great Dane also love this toy. It's about the size of a soccer ball and covered in a nice rubber that can be chewed off if you have a destructive player but is more than durable enough for tossing around the house or even in the yard. Chewability-wise, The Dane managed to chew a couple of chunks off the handle part but he's probably a pretty extreme example. I think this would hold up just fine for most dogs' play. I just have to supervise it with my Dane so that he doesn't chew it into a pile of rubber.
The biggest surprise of this ball was the fact that it has one of those slide whistles in it that makes a noise as it tumbles and rolls around. This proved irresistible to the Golden Retriever and the Lab. Every time they hear the slide whistle inside, they get up from wherever they are and focus 100% on this ball.
It has some heft to it and it bounces a little but not as much as a regular ball its size, it's fun for the little ones to play with inside but it's primarily an outdoor dog toy. The handles are big enough for a human hand to hold them comfortably. It rolls in a hard-to-predict way that is extra helpful for the smaller dogs to chase.
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Reviewed in the United States on December 22, 2025