NMN Pro 250™ Sustained Release - Uthever® NMN, 250 mg, 60 tabs - Living Machine™ - 3-Pack
SKU: 12783444221

NMN Pro 250™ Sustained Release - Uthever® NMN, 250 mg, 60 tabs - Living Machine™ - 3-Pack

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Description

NMN Pro 250™ Sustained Release - Uthever® NMN, 250 mg, 60 tabs - Living Machine™ - 3-PackCombat Aging, Improve Heart Health and Promote Muscle Strength NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, body weight and gene expression. Nicotinamide mononucleotide (NMN) is a derivative of the B vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+. NMN Pro 250 Sustained Release is

Combat Aging, Improve Heart Health and Promote Muscle Strength

  • NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, body weight and gene expression.
  • Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+.
  • NMN Pro 250 Sustained Release is designed to slow and prolong NMN absorption, allowing a longer steady blood level concentration of the active ingredient. This enables NMN Pro 250 Sustained Release to be given at higher doses less frequently.

View Certificate of Analysis

Research Supported Benefits:

Supports Longevity. Studies have shown that boosting NAD+ synthesis in the body extends the lifespan of yeast, worms and flies. (1)

Blood Sugar Regulation. As we age, we have more trouble processing glucose, leading to higher blood sugar. Supplemental NMN is shown to improve several markers of skeletal muscle glucose metabolism that are commonly dysregulated in people with metabolic disorders. (2)

Supports Metabolism and Healthy Weight. Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NMN can help to reverse this while improving metabolic pathways to maintain a healthy weight. (3,4,5)

Supports Healthy Cognition. Declining cognitive function with age is related to a reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NMN may be able to prevent this dysfunction. (6,7)

Supports Healthy Skin. In our 30s and 40s, the appearance of our skin can start to show signs of age. Several studies have examined how boosting NAD+ levels in the skin prevents premature skin aging or supports a healthier external appearance. (8,9)

References:

1. Fang EF, Kassahun H, Croteau DL, et al. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016;24(4):566-581. doi:10.1016/j.cmet.2016.09.004

2. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287

3. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287

4. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021;31(4):356-364. doi:10.1080/08982104.2020.1820521

5. Katayoshi T, Nakajo T, Tsuji-Naito K. Restoring NAD+ by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. J Photochem Photobiol B. 2021;221:112238. doi:10.1016/j.jphotobiol.2021.112238

6. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(4):755. Published 2022 Feb 11. doi:10.3390/nu14040755

7. Kiss T, Nyúl-Tóth Á, Balasubramanian P, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020;42(2):527-546. doi:10.1007/s11357-020-00165-5

8. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186/s12970-021-00442-

9. Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013

10. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016/j.redox.2019.101192

11. Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016/j.brainres.2016.04.060

12. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016/j.cmet.2011.08.014

13. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126/science.abe9985

Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 60
Amount Per Serving %DV
Uthever® β-Nicotinamide mononudeotide (NMN)
250 mg
† Daily Value not established
REV. 10.23
  • OTHER INGREDIENTS: Isomalt, modified pea protein, stearic acid, calcium palmitate, hydroxypropyl cellulose, pharmaceutical glaze.
  • SUGGESTED DAILY USE: Take 1 to 4 tablets in the morning, or as recommended by your healthcare practitioner.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. KEEP OUT OF REACH OF CHILDREN 
  • Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in energy production, metabolism and gene expression in the body. When we boost NMN levels in the body, we can enhance the biosynthesis of NAD+ and alleviate symptoms associated with depletion of this crucial nutrient. NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, brain health, heart health, body weight and gene expression.
  • NMN Pro 250 Sustained Release is designed to significantly enhance NAD+ production and absorption by raising NMN and NAD+ blood levels for up to 6 hours compared to approximately 6 minutes for non-stabilized NMN in animal studies. The gel barrier around the tablet effectively protects the NMN from harsh gastrointestinal acids and upon reaching the intestines can be released slowly.
  • Only Clincially-Proven NMN. ProHealth’s NMN is the only clinically-proven NMN to boost NAD+ levels in a peer-reviewed, double-blind, placebo-controlled, published, clinical study. Results of the study indicated a 38% increase in NAD+ levels and 12-year reversal in biological age.
  • Unique Delivery Method. NMN Pro 250 Sustained Release is designed to significantly enhance NAD+ production and absorption by raising NMN and NAD+ blood levels for up to 6 hours compared to approximately 6 minutes for non-stabilized NMN in animal studies. The gel barrier around the tablet effectively protects the NMN from harsh gastrointestinal acids and upon reaching the intestines can be released slowly.
  • Solvent-Free. Compared to other NMN products, ours is made without any chemical solvents.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
Be Aware of Fake NMN: Fraudulent companies are always attempting to out-price competitors by using NMN fake ingredients to gain market share, which is not fair to you, the consumer, or the reputable companies, like ProHealth that spends time and resources to ensure a safe and pure NMN product.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
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  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 12783444221

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4.6 ★★★★★
Based on 1135 reviews
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Verified Purchase
Valerii Starikov
Carnegie, US
★★★★★ 5
Very Comfortable Ergonomic Chair - Great for Long Work Days!
Color: Black, Color: Black
I’ve been using this ergonomic office chair for a couple of weeks now and I’m genuinely impressed. For the price, it offers excellent comfort and support. What I like: • Very comfortable padded seat and backrest — I can sit for 8+ hours without back pain. • Good lumbar support and adjustable height/armrests. • Holds up to 330 lbs easily (I’m 240 lbs and it feels very stable). • Smooth rolling wheels and sturdy base. • Easy to assemble (took about 20 minutes). The mesh back breathes well and doesn’t get hot. It looks professional in my home office too. Overall, this is a solid ergonomic chair. If you spend a lot of time at a desk, I highly recommend it. Would I buy it again? Yes, definitely.
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Reviewed in the United States on May 12, 2026
O
Verified Purchase
Ordray
Bozeman, US
★★★★★ 4
Great if you're average height.
Color: Black
Comfortable for the price. The seat could be a bit better, but for a budget friendly ergonomic chair, it's well made and has helped a lot with my back pain caused by my previous desk chair. Assembly wasn't terribly difficult, though I did have one screw with damaged threads. Luckily they ship spare screws in the kit, so that was a non-issue. Rollers work great on my small rug and hard flooring and don't tend to tangle cords or cables too much. Size wise, works great for my frame (5 ft 6 in) but for someone more than a few inches taller than myself, you should probably look at another chair.
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Reviewed in the United States on September 4, 2025
W
Verified Purchase
Wilbert Bean
Massapequa, US
★★★★★ 5
Great chair
Color: Black
I am very happy with my purchase. Easy to assemble but be aware your drill bits included with your set won't fit their screws. However, you can get a fair bit done with the drill and then use tool included to adjust. Super comfortable and exactly the right height for my desk. Highly recommend for quality exceeding price point.
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Reviewed in the United States on May 9, 2026
D
Verified Purchase
Dave
Boise, US
★★★★★ 1
Review from an "actual" tall person who doesn't weigh 400 pounds.
Color: Black
I recommend this chair. Firstly, I looked at least dozens of chairs and nearly every review in trying to select a chair. I didn't want to spend $200. It's confusing because everyone's idea of perfect is of course subjective. One thing, What is tall? I'm 6'6" I think that's pretty tall. Others feel that 6'0" is tall. LOL In the listing, it shows this chair is good for a 6'5" person which I think is pretty accurate. I weigh about 210 pounds and the padding is just fine. One thing I would push manufacturers to do would be to give accurate measurements. Seat height low and high. Back support height. Head rest added to back height etc.! Maybe actual human measurements that the chair is geared toward. Nice to know that 400 lbs is cool but that doesn't tell me much. My primary goal was to find a chair I could sleep in because I recently had a back injury and sleeping on my bed, while fine, resulted in intense pain trying to get up in the morning. We'll see what happens but the headrest reaches my head which was goal one. The lumbar fits so I don't need to use cushions and pads etc. I found the upper position of the support to be right for me and it's super comfortable. Plus number two. The raised height of the chair fits my long legs (inseam 36") Plus three. I wanted adjustable arm rests but this one doesn't have that. No biggie, for me the height of the arm rests is pretty much just right. It might be a little high for some. The back leaning adjustment doesn't lock except for upright. Locking upright is good, and leaning back - for me - doesn't really need to lock. Being an actual tall person made me really skeptical. I'm relieved that I won't have to take it apart to return it. The assembly was straight forward and pretty easy though I'd suggest not really tightening the arms snugly before getting the back squared away - the alignment is easier if you do that. I got the chair for $109 with 21% off. It's slightly wobbly yet feels pretty well made. It rolls well enough. I'm quite satisfied with the purchase and I'll come back if there are updates. Edit one. I've had it a week now and found I couldn't sleep in it. I think it would be better if the back could recline separately from the seat. There might also be figuring out a way to support my legs due to the back and seat reclining together rather than separately. Two. I kind of wish more now that the arms were adjustable for height and tilt if that makes sense. I have a bar stool next to me on the right in front of my desk that is the right height to relax my right arm while reaching my mouse on the desk so that's my work around there. Three. The casters are kind of basic and don't roll as easily on the floor matt as my former second hand chair - they would probably be fine on a hard surface. I'll probably switch them out. Four: The lumbar support, while mostly in the right place is unpadded and creates kind of a hard spot there. I've re-introduced my lumbar support pillows for comfort there. All in all, I'm still happy with the $100 purchase. In my experience, being pretty tall always comes with compromise and these notes are not deal breakers for me. Yea, It can always be more perfect but unless you're in a showroom test driving and willing to spend $300? Right. UPDATE: I'm really not satisfied with this chair and in fact, I wish I hadn't bought it. Firstly, the pneumatic post that the chair part connects with is wobbly depending on which way it is facing according to which way the legs are aligned. It's like a poor fit and I'm pretty mechanically inclined. Second and also important. The lock to keep it upright and inclined only worked for a few weeks. For a while, you had to mess with it to engage the upright position. It no longer works. Worse than that, the lumbar support pad disconnected with the chair and is now floating and after only a month or so, the remaining supports for the Lumbar rest have dug into the fabric on the back of the chair creating holes in the back's fabric. I've tried but there is no way to reconnect that bit without removing the back's fabric as far as I can see. I'm taking this down to one star for sure. Poor design? Poor manufacturing? Yea. I wouldn't suggest this chair to anyone. If the company comes up with a solution, I'll continue my review. As for now. Not a recommendation. Update: Not impressed and kind of crappy. Mentioned is that the so called lumbar thingy disconnected and is unusable. I've got my own pad which seems to help. Also, it's wiggly where the chair connects to the base. Months later, I might toss it and go back to the chair I bought locally and second hand. Don't buy this chair!
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Reviewed in the United States on March 20, 2025
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Verified Purchase
QZ
Port Orchard, US
★★★★★ 5
Great Instructions, Straightforward Assembly
Color: Black
I just received this chair today, so my product review is mostly on the packaging, instructions, and assembly. The product was well-packaged, and it was obvious when I unboxed it that a lot of care and thought went into packing it in the most efficient way that would also protect the parts. I was positively impressed with the packaging. I was also incredibly impressed with the instructions and assembly process. I am used to cheaper products where the parts only half fit or important components are missing, or where the instructions were confusing and unclear. This chair's instruction manual was very clear and concise. The diagrams were easy to understand and neat. The screws came labeled and separated and also included the scew types and sizes/lengths, which is handy in case you need to pick up extras at a store somewhere. But they also included one extra of each type of screw, washer, and cover, which I appreciated during assembly. (I didn't find myself worrying what would happen if I dropped a screw, which is something I would normally be distsracted by while working.) The only things I would take points off for were these: 1. The instructions said the chair came with gloves for assembly, but no gloves were included. That was fine with me, but why mention them if you won't include them? The instructions even later say not to use the chair if not all components were present...but all the important ones were, so I assembled it without gloves (as I probably would have done anyway, since it was for me and not another person). 2. It matters which side of the seat is the front, but the sticker was confusing. The instructions show a sticker placed on the side that is the front, and that is where my sticker was placed. However, the sticker says "FRONT" and has an arrow pointing somewhere. In the instructions this arrow pointed to the front. On my seat, however, the arrow pointed to the back. So am I supposed to believe the sticker placement (it was diagonal, so it looked haphazardly slapped on) or the arrow? On that particular step the piece you are screwing into the seat can fit both ways, but thankfully there is a later step where it becomes obvious which side is the front vs. the back. (The arm rests can only be attached to the back.) So I wish that had been clearer up front, but otherwise it was okay. Recommendations for assembly: - To attach the wheels, apply firm, direct, straight-down pressure. I tried screwing them on at first but you just push. Make sure they go in the whole way like the picture shows. - When they say to tighten the screws to only 60%, it's a helpful tip, because you can't fit the armrests on both the seat and chairback at the same time with the screws completely tightened. Just tighten them enough to fit the pieces on, then later you can tighten up the screws. So far I find the chair to be very comfortable and I'm exceedingly happy with it. The lumbar support seems like it could potentially be a little chafy or scratchy, but I'll give the chair a chance before deciding if it's problematic or not. Like I said, I only got the chair today, so I can't speak much to its long-term comfort, durability, or longevity. But I was so impressed with how easy and straightforward they made the assembly that I had to write a review to show my appreciation.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 9, 2026

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